The natural PA66 (Nylon 6/6) insulator handles the usual under-hood and industrial cabinet temperature range of -25°C to 105°C.
The Contacts Situation — What You Actually Need to Order
TE does not publish a single compatible contact part number in the MIS series documentation that covers all wire gauges, but the general rule for this series is a crimp socket terminal that fits 2.50 mm centerline spacing. If you are replacing a connector in an existing harness, the original terminal part number is the one to reorder; for a new build, the TE application tooling guide for the MIS series lists the contact part numbers by wire size. The housing itself is RoHS compliant.